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Demystifying a hexuronic acid ligand that recognizes Toxoplasma gondii and blocks its invasion into host cells

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Abstract

Toxoplasma gondii is a ubiquitous eukaryotic pathogen responsible for toxoplasmosis in humans and animals. This parasite is an obligate intracellular pathogen and actively invades susceptible host cells, a process which is mediated by specific receptor–ligand interactions. Here, we have identified an unnatural 2,4-disulfated D-glucuronic acid (Di-S-GlcA), a hexuronic acid composed of heparin/heparan sulfate, as a potential carbohydrate ligand that can selectively bind to T. gondii parasites. More importantly, the gelatin conjugated Di-S-GlcA multivalent probe displayed strong inhibition of parasite entry into host cells. These results open perspective for the future use of Di-S-GlcA epitopes in biomedical applications against toxoplasmosis.

Graphical abstract: Demystifying a hexuronic acid ligand that recognizes Toxoplasma gondii and blocks its invasion into host cells

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Publication details

The article was received on 01 Apr 2019, accepted on 09 Apr 2019 and first published on 09 Apr 2019


Article type: Paper
DOI: 10.1039/C9OB00744J
Citation: Org. Biomol. Chem., 2019, Advance Article

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    Demystifying a hexuronic acid ligand that recognizes Toxoplasma gondii and blocks its invasion into host cells

    B. Subramani, C. D. Shantamurthy, P. Maru, M. A. Belekar, S. Mardhekar, D. Shanmugam and R. Kikkeri, Org. Biomol. Chem., 2019, Advance Article , DOI: 10.1039/C9OB00744J

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