Synthesis of pyrazolylvinyl ketones from furan derivatives†
A new protocol for the synthesis of pyrazol-5-ylvinyl ketones, e.g. pyrazole-chalcones, employing furfuryl ketones as a triketone equivalent, has been developed. The reaction occurs under mild conditions and does not require the use of expensive materials. Other important benefits include the simplicity and atom efficiency of this approach.
- This article is part of the themed collection: Synthetic methodology in OBC