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Issue 16, 2019
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Mechanistic investigation of superelectrophilic activation of 1,1′-bi-2-naphthols in the presence of aluminum halides

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Abstract

7,7′-Dihydroxy-1,1′-bi-2-naphthol, as a result of superelectrophilic activation in the presence of an excess of aluminum halides, reacts with cyclohexane and benzene to yield 5,6,7,8,5′,6′,7′,8′-octahydro-7,7′-dioxo-bi-2-naphthol and its 5,5′-diphenyl derivative, respectively. In contrast, isomeric 6,6′-dihydroxy-1,1′-bi-2-naphthol does not react at all under the same reaction conditions, while the parent 1,1′-bi-2-naphthol (BINOL) reveals an alternative mode of behavior. The mechanistic aspects of these intriguing results are discussed on the basis of experimental and theoretical (DFT) study of the protonation and complexation properties of the starting BINOLs.

Graphical abstract: Mechanistic investigation of superelectrophilic activation of 1,1′-bi-2-naphthols in the presence of aluminum halides

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Publication details

The article was received on 19 Mar 2019, accepted on 25 Mar 2019 and first published on 27 Mar 2019


Article type: Paper
DOI: 10.1039/C9OB00640K
Citation: Org. Biomol. Chem., 2019,17, 3971-3977

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    Mechanistic investigation of superelectrophilic activation of 1,1′-bi-2-naphthols in the presence of aluminum halides

    Z. Zhu, A. M. Genaev, G. E. Salnikov and K. Yu. Koltunov, Org. Biomol. Chem., 2019, 17, 3971
    DOI: 10.1039/C9OB00640K

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