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Transition metal-free functionalized hydration of alkynes: one-pot synthesis of fluorinated β-keto-imidates using Selectfluor

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Abstract

A transition metal-free, four-component one-pot synthesis of polyfunctionalized fluorinated β-keto-imidates via the functionalized hydration of alkynes has been described. The intermediate 1,3-ketoamino moiety was obtained from easily accessible arylpropioladehyde and arlyhydroxylamine and was treated with Selectfluor delivering fluorinated β-keto-imidates. A wide variety of functional groups are tolerated under mild reaction conditions and the product applicability is highlighted.

Graphical abstract: Transition metal-free functionalized hydration of alkynes: one-pot synthesis of fluorinated β-keto-imidates using Selectfluor

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Publication details

The article was received on 04 Mar 2019, accepted on 29 Mar 2019 and first published on 01 Apr 2019


Article type: Communication
DOI: 10.1039/C9OB00527G
Citation: Org. Biomol. Chem., 2019, Advance Article

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    Transition metal-free functionalized hydration of alkynes: one-pot synthesis of fluorinated β-keto-imidates using Selectfluor

    A. Ghosh, R. Hegde, V. B. Makane, B. Sridhar, H. B. Rode, S. A. Patil and R. B. Dateer, Org. Biomol. Chem., 2019, Advance Article , DOI: 10.1039/C9OB00527G

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