Chemical ADP-ribosylation: mono-ADPr-peptides and oligo-ADP-ribose
ADP-ribosylation is an important post-translational modification that plays a pivotal role in many cellular processes, including cell signaling, DNA repair, gene regulation and apoptosis. Although synthetic mono- or poly-ADP-ribosylated biomolecules are extremely challenging in terms of the difficulties in regio- and stereoselective glycosylation, suitable protective groups manipulations and pyrophosphate construction, chemical synthesis towards these bio-related targets has been reported in recent years. Chemically synthesized well-defined ADP-ribose derivatives serve as useful tools in biological experiments aimed to further elucidate native ADP-ribosylation. In this Review, we will discuss the synthetic advances of mono-ADP-ribosylated protein/peptide and oligo-ADP-ribose chains. Future possible synthetic targets and upcoming new methods for the synthesis of these molecules are also included.
- This article is part of the themed collection: Chemical biology in OBC