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Issue 17, 2019
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Metal- and radical-free aerobic oxidation of heteroaromatic methanes: an efficient synthesis of heteroaromatic aldehydes

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Abstract

A metal-free and radical-free synthesis of heteroaromatic aldehydes was developed through aerobic oxidation of methyl groups in an I2/DMSO/O2 catalytic system. Under the reaction conditions, various functional groups such as methoxy, aldehyde, ester, nitro, amide, and halo (F, Cl, Br) groups were well tolerated. The bioactive compounds like chlorchinaldin derivative and papaverine were also oxidized to the corresponding aldehydes and ketones. This reaction provided an efficient method for preparing the valuable heteroaromatic aldehydes.

Graphical abstract: Metal- and radical-free aerobic oxidation of heteroaromatic methanes: an efficient synthesis of heteroaromatic aldehydes

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Publication details

The article was received on 27 Feb 2019, accepted on 28 Mar 2019 and first published on 29 Mar 2019


Article type: Communication
DOI: 10.1039/C9OB00490D
Org. Biomol. Chem., 2019,17, 4220-4224

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    Metal- and radical-free aerobic oxidation of heteroaromatic methanes: an efficient synthesis of heteroaromatic aldehydes

    R. Ye, Y. Cao, X. Xi, L. Liu and T. Chen, Org. Biomol. Chem., 2019, 17, 4220
    DOI: 10.1039/C9OB00490D

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