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Pd-Catalyzed directed CH-(hetero)arylation of cyclic α-amino acids: effects of substituents and the ring size

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Abstract

A systematic study on the directed Pd-catalyzed (hetero)arylation of 26 substituted cyclic α-amino acids at the C(3)-atom was performed. For the first time, the 7- and 8-membered cyclic amino acids were introduced to C–H activation. 8-Aminoquinoline was used as a directing group. Effects of the ring size and the substituents on the reaction efficacy and stereoselectivity were studied.

Graphical abstract: Pd-Catalyzed directed CH-(hetero)arylation of cyclic α-amino acids: effects of substituents and the ring size

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Publication details

The article was received on 17 Feb 2019, accepted on 27 Mar 2019 and first published on 27 Mar 2019


Article type: Paper
DOI: 10.1039/C9OB00393B
Citation: Org. Biomol. Chem., 2019, Advance Article

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    Pd-Catalyzed directed CH-(hetero)arylation of cyclic α-amino acids: effects of substituents and the ring size

    V. Hutskalova and P. K. Mykhailiuk, Org. Biomol. Chem., 2019, Advance Article , DOI: 10.1039/C9OB00393B

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