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Mild and regioselective azol-halogenation of alkenes

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Abstract

An economical and practical azol-halogenation protocol of alkenes, which provides a general approach to construct a series of structurally diverse β-halogenated amine derivatives, is reported. The wide substrate scope, good functional group tolerance, ease of large-scale preparation and potential for product derivatization make this reaction attractive. Mechanistic studies suggest that the azol-halogenation process might involve a radical halogenation followed by nucleophilic azolyation.

Graphical abstract: Mild and regioselective azol-halogenation of alkenes

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Publication details

The article was received on 09 Feb 2019, accepted on 26 Mar 2019 and first published on 27 Mar 2019


Article type: Communication
DOI: 10.1039/C9OB00317G
Citation: Org. Biomol. Chem., 2019, Advance Article

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    Mild and regioselective azol-halogenation of alkenes

    K. Sun, B. Luan, Z. Liu, J. Zhu, J. Du, E. Bai, Y. Fang and B. Zhang, Org. Biomol. Chem., 2019, Advance Article , DOI: 10.1039/C9OB00317G

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