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A facile one pot synthesis of thiazolo[3,2-a]benzimidazole and pyran fused polyheterocyclic scaffolds

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Abstract

An efficient synthesis of dihydro-4H-benzo[4,5]imidazo[2,1-b]pyrano[2,3-d]thiazole by a multicomponent route starting from 2-((1H-benzo[d]imidazol-2-yl)thio)-1-phenylethan-1-one, an aromatic aldehyde and malononitrile is described. This protocol features a metal free approach with good substrate scope and decent yield. The heterocyclic skeleton obtained in this study may have interesting biological properties.

Graphical abstract: A facile one pot synthesis of thiazolo[3,2-a]benzimidazole and pyran fused polyheterocyclic scaffolds

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Publication details

The article was received on 07 Feb 2019, accepted on 25 Mar 2019 and first published on 25 Mar 2019


Article type: Communication
DOI: 10.1039/C9OB00300B
Citation: Org. Biomol. Chem., 2019, Advance Article

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    A facile one pot synthesis of thiazolo[3,2-a]benzimidazole and pyran fused polyheterocyclic scaffolds

    A. Mariappan, K. Rajaguru, S. Muthusubramanian and N. Bhuvanesh, Org. Biomol. Chem., 2019, Advance Article , DOI: 10.1039/C9OB00300B

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