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Issue 13, 2019
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Iodine-mediated oxidative N–N coupling of secondary amines to hydrazines

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Abstract

An I2-mediated N–N coupling reaction has been established for oxidative dimerization of N-aryl aminopyridines to a variety of novel hydrazine derivatives under mild conditions. This synthetic method does not require use of transition metals and can be conveniently carried out on a gram scale. It is also applicable to diphenylamine and N-alkyl aniline substrates.

Graphical abstract: Iodine-mediated oxidative N–N coupling of secondary amines to hydrazines

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Article information


Submitted
02 Feb 2019
Accepted
12 Mar 2019
First published
12 Mar 2019

Org. Biomol. Chem., 2019,17, 3446-3450
Article type
Paper

Iodine-mediated oxidative N–N coupling of secondary amines to hydrazines

L. Ren, M. Wang, B. Fang, W. Yu and J. Chang, Org. Biomol. Chem., 2019, 17, 3446
DOI: 10.1039/C9OB00279K

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