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Issue 10, 2019
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Glycoconjugate synthesis using chemoselective ligation

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Chemoselective ligation of carbohydrates and polypeptides was achieved using an adipic acid dihydrazide cross-linker. The reducing end of a carbohydrate is efficiently attached to peptides in two steps, constructing a glycoconjugate in high yield and with high regioselectivity, enabling the production of homogeneous glycoconjugates.

Graphical abstract: Glycoconjugate synthesis using chemoselective ligation

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Article information

01 Feb 2019
12 Feb 2019
First published
12 Feb 2019

Org. Biomol. Chem., 2019,17, 2646-2650
Article type

Glycoconjugate synthesis using chemoselective ligation

S. Cheng, P. L. Wantuch, M. E. Kizer, D. R. Middleton, R. Wang, M. DiBello, M. Li, X. Wang, X. Li, V. Ramachandiran, F. Y. Avci, F. Zhang, X. Zhang and R. J. Linhardt, Org. Biomol. Chem., 2019, 17, 2646
DOI: 10.1039/C9OB00270G

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