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Issue 10, 2019
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Glycoconjugate synthesis using chemoselective ligation

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Abstract

Chemoselective ligation of carbohydrates and polypeptides was achieved using an adipic acid dihydrazide cross-linker. The reducing end of a carbohydrate is efficiently attached to peptides in two steps, constructing a glycoconjugate in high yield and with high regioselectivity, enabling the production of homogeneous glycoconjugates.

Graphical abstract: Glycoconjugate synthesis using chemoselective ligation

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Publication details

The article was received on 01 Feb 2019, accepted on 12 Feb 2019 and first published on 12 Feb 2019


Article type: Communication
DOI: 10.1039/C9OB00270G
Citation: Org. Biomol. Chem., 2019,17, 2646-2650

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    Glycoconjugate synthesis using chemoselective ligation

    S. Cheng, P. L. Wantuch, M. E. Kizer, D. R. Middleton, R. Wang, M. DiBello, M. Li, X. Wang, X. Li, V. Ramachandiran, F. Y. Avci, F. Zhang, X. Zhang and R. J. Linhardt, Org. Biomol. Chem., 2019, 17, 2646
    DOI: 10.1039/C9OB00270G

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