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Solid phase syntheses of peptoid like arylureido compounds and sequencing of isobars without molecular encoding

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Abstract

Arylureido-backbone containing peptoid-like trimers were prepared using the one-bead-one-compound approach. Isobaric molecules were synthesized from isocyanate precursors that contain alkyl halide handles at the ortho and para-positions in the phenyl ring. After chain extension with a primary amine, the piperazine-capped molecules were sequenced using tandem mass spectrometry and successfully identified based on their fragmentation pattern without a need for internal molecular encoding.

Graphical abstract: Solid phase syntheses of peptoid like arylureido compounds and sequencing of isobars without molecular encoding

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Publication details

The article was received on 25 Jan 2019, accepted on 24 Mar 2019 and first published on 25 Mar 2019


Article type: Communication
DOI: 10.1039/C9OB00205G
Citation: Org. Biomol. Chem., 2019, Advance Article

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    Solid phase syntheses of peptoid like arylureido compounds and sequencing of isobars without molecular encoding

    K. Asif, G. L. O'Brien, S. M. Goodman and S. Suwal, Org. Biomol. Chem., 2019, Advance Article , DOI: 10.1039/C9OB00205G

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