Piotr Szcześniak, Olga Staszewska-Krajewska and Jacek Mlynarski
Org. Biomol. Chem., 2019,17, 3225-3231
DOI:
10.1039/C9OB00178F,
Paper
Asymmetric total synthesis of (+)-asenapine, an atypical antipsychotic drug, used for treating schizophrenia and acute mania associated with bipolar disorder, is reported. The key steps are the organocatalytic Michael addition of aldehydes to trans-nitroalkenes and subsequent reductive cyclization.
