Issue 13, 2019

Cobalt-catalyzed C2α-acyloxylation of 2-substituted indoles with tert-butyl peresters

Abstract

An efficient cobalt-catalyzed C2α selective C(sp3)–H acyloxylation of 2-substituted indoles with tert-butyl peresters to synthesize diverse 2α-acyloxylated indole derivatives is described. This newly developed method exhibits mild conditions, low-cost catalyst, and high functional group compatibility. In addition, the effectiveness of this chemistry is illuminated by a late-stage modification of methylated indomethacin.

Graphical abstract: Cobalt-catalyzed C2α-acyloxylation of 2-substituted indoles with tert-butyl peresters

Supplementary files

Article information

Article type
Communication
Submitted
21 Jan 2019
Accepted
05 Mar 2019
First published
13 Mar 2019

Org. Biomol. Chem., 2019,17, 3343-3347

Cobalt-catalyzed C2α-acyloxylation of 2-substituted indoles with tert-butyl peresters

Y. Zhou, C. Li, X. Yuan, F. Zhang, X. Liu and P. Liu, Org. Biomol. Chem., 2019, 17, 3343 DOI: 10.1039/C9OB00159J

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