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Issue 9, 2019
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Copper-catalyzed carbene/alkyne metathesis terminated with the Buchner reaction: synthesis of dihydrocyclohepta[b]indoles

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Abstract

A copper-catalyzed selective cascade reaction of alkyne-tethered diazo compounds is reported for the direct and efficient construction of dihydrocyclohepta[b]indole skeletons under mild reaction conditions. A vinyl copper carbene is the key intermediate, which is generated in situ via carbene/alkyne metathesis (CAM) and terminated with the Buchner reaction.

Graphical abstract: Copper-catalyzed carbene/alkyne metathesis terminated with the Buchner reaction: synthesis of dihydrocyclohepta[b]indoles

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Publication details

The article was received on 16 Jan 2019, accepted on 31 Jan 2019 and first published on 31 Jan 2019


Article type: Communication
DOI: 10.1039/C9OB00113A
Citation: Org. Biomol. Chem., 2019,17, 2326-2330

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    Copper-catalyzed carbene/alkyne metathesis terminated with the Buchner reaction: synthesis of dihydrocyclohepta[b]indoles

    Q. Zeng, K. Dong, J. Huang, L. Qiu and X. Xu, Org. Biomol. Chem., 2019, 17, 2326
    DOI: 10.1039/C9OB00113A

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