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Issue 8, 2019
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Versispiroketal A, an unusual tetracyclic bridged spiroketal from the sponge-associated fungus Aspergillus versicolor SCSIO 41013

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Abstract

Versispiroketal A (1), an unprecedented 6/5/5/6 tetracyclic polyketide featuring a rarely encountered bridge-fused spiroketal skeleton, was isolated from the sponge-associated fungus Aspergillus versicolor SCSIO 41013. The structure and absolute configuration of 1 were unequivocally determined by comprehensive spectroscopic analysis, single-crystal X-ray diffraction analysis and quantum chemical ECD calculations. Compound 1 showed weak cytotoxicity against four cancer cell lines. A plausible biosynthetic pathway for 1 was also postulated.

Graphical abstract: Versispiroketal A, an unusual tetracyclic bridged spiroketal from the sponge-associated fungus Aspergillus versicolor SCSIO 41013

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Publication details

The article was received on 16 Jan 2019, accepted on 28 Jan 2019 and first published on 29 Jan 2019


Article type: Paper
DOI: 10.1039/C9OB00110G
Org. Biomol. Chem., 2019,17, 2182-2186

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    Versispiroketal A, an unusual tetracyclic bridged spiroketal from the sponge-associated fungus Aspergillus versicolor SCSIO 41013

    L. Salendra, X. Luo, X. Lin, J. Wang, B. Yang, X. Zhou and Y. Liu, Org. Biomol. Chem., 2019, 17, 2182
    DOI: 10.1039/C9OB00110G

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