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Issue 12, 2019
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Modular synthesis and immunological evaluation of suspected allergenic galactooligosaccharides

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Abstract

Galactooligosaccharides (GOS) are widely used in the food industry as prebiotics and in very rare cases, can lead to an allergic reaction. Due to the microheterogeneity of GOS it is very difficult to extract pure and well defined oligosaccharides to establish which component is responsible for the observed allergenicity. Herein, we report the chemical synthesis of a suspected allergen 4PX and three closely related oligosaccharides based on a modular approach. The fact that synthesized 4PX and a regioisomer did not cause basophil activation in subjects with confirmed GOS-allergy excludes both tetrasaccharides as key-epitopes in GOS-allergenicity in Singapore.

Graphical abstract: Modular synthesis and immunological evaluation of suspected allergenic galactooligosaccharides

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Publication details

The article was received on 15 Jan 2019, accepted on 26 Feb 2019 and first published on 26 Feb 2019


Article type: Communication
DOI: 10.1039/C9OB00108E
Org. Biomol. Chem., 2019,17, 3108-3112

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    Modular synthesis and immunological evaluation of suspected allergenic galactooligosaccharides

    H. Elferink, E. Rossing, C. Huang, B. W. Lee, L. Cao, D. J. Delsing, A. Groeneveld and T. J. Boltje, Org. Biomol. Chem., 2019, 17, 3108
    DOI: 10.1039/C9OB00108E

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