Jump to main content
Jump to site search

Issue 8, 2019
Previous Article Next Article

Photo-sensitized oxy-thiocyanation of terminal alkynes/1,3-aryldienes and their one-pot conversion to 2-hydroxy 4-substituted aryl thiazoles

Author affiliations

Abstract

A regioselective visible light induced synthesis of aryl α-thiocyano ketones/thiocyano alcohols from activated terminal aryl alkynes and aryl 1,3-conjugated dienes was achieved. This mild and non-metallic oxidation is exclusively driven by benign ambient air in the presence of an organic photo-catalyst and NH4SCN. This protocol was also demonstrated at the 5 mmol scale for the synthesis of potentially therapeutic 2-hydroxy 4-substituted arylthiazoles in good yields, signifying its amenability for large-scale application.

Graphical abstract: Photo-sensitized oxy-thiocyanation of terminal alkynes/1,3-aryldienes and their one-pot conversion to 2-hydroxy 4-substituted aryl thiazoles

Back to tab navigation

Supplementary files

Publication details

The article was received on 09 Jan 2019, accepted on 25 Jan 2019 and first published on 26 Jan 2019


Article type: Paper
DOI: 10.1039/C9OB00054B
Citation: Org. Biomol. Chem., 2019,17, 2232-2241

  •   Request permissions

    Photo-sensitized oxy-thiocyanation of terminal alkynes/1,3-aryldienes and their one-pot conversion to 2-hydroxy 4-substituted aryl thiazoles

    K. Gullapalli and S. Vijaykumar, Org. Biomol. Chem., 2019, 17, 2232
    DOI: 10.1039/C9OB00054B

Search articles by author

Spotlight

Advertisements