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Synthesis of quinazolin-4(1H)-ones via amination and annulation of amidines and benzamides

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Abstract

Quinazolinones have broad applications in the biological, pharmaceutical and material fields. Studies on the synthesis of these compounds are therefore widely conducted. Herein, a novel and highly efficient copper-mediated tandem C(sp2)–H amination and annulation of benzamides and amidines for the synthesis of quinazolin-4(1H)-ones is proposed. This synthetic route can be useful for the construction of quinazolin-4(1H)-one frameworks.

Graphical abstract: Synthesis of quinazolin-4(1H)-ones via amination and annulation of amidines and benzamides

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Publication details

The article was received on 04 Jan 2019, accepted on 06 Feb 2019 and first published on 07 Feb 2019


Article type: Communication
DOI: 10.1039/C9OB00020H
Citation: Org. Biomol. Chem., 2019, Advance Article

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    Synthesis of quinazolin-4(1H)-ones via amination and annulation of amidines and benzamides

    F. Hu, X. Cui, Z. Ban, G. Lu, N. Luo and G. Huang, Org. Biomol. Chem., 2019, Advance Article , DOI: 10.1039/C9OB00020H

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