Jump to main content
Jump to site search


An NHC-catalyzed, stereoselective α-functionalization of α,β-unsaturated carboxylic acids through in situ activation

Author affiliations

Abstract

An N-heterocyclic carbene (NHC)-catalyzed α-functionalization of the in situ activated α,β-unsaturated carboxylic acids bearing γ-H was realized through formal [4 + 2] annulations with o-quinone methides, which paved a new avenue for the assembly and modification of the dihydrocoumarin scaffold in good yields with excellent diastereo- and enantioselectivities.

Graphical abstract: An NHC-catalyzed, stereoselective α-functionalization of α,β-unsaturated carboxylic acids through in situ activation

Back to tab navigation

Supplementary files

Publication details

The article was received on 26 Dec 2018, accepted on 09 Apr 2019 and first published on 10 Apr 2019


Article type: Paper
DOI: 10.1039/C8OB03206H
Citation: Org. Biomol. Chem., 2019, Advance Article

  •   Request permissions

    An NHC-catalyzed, stereoselective α-functionalization of α,β-unsaturated carboxylic acids through in situ activation

    Z. Wang, H. Zhang, H. Qian, Y. Wang, C. Yu, T. Li and C. Yao, Org. Biomol. Chem., 2019, Advance Article , DOI: 10.1039/C8OB03206H

Search articles by author

Spotlight

Advertisements