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Aryltrifluoromethylative cyclization of unactivated alkenes by the use of PhICF3Cl under catalyst-free conditions

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Abstract

A concise and catalyst-free aryltrifluoromethylative cyclization of unactivated alkenes has been developed herein. The use of PhICF3Cl as a powerful trifluoromethylating agent allows easy transformations. A set of trifluoroethylated carbocycles and aza-hereocycles were efficiently synthesized in good yield and selectivity. A broad substrate scope, mild reaction conditions, and easy operation would make this method well-suited for applications.

Graphical abstract: Aryltrifluoromethylative cyclization of unactivated alkenes by the use of PhICF3Cl under catalyst-free conditions

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Publication details

The article was received on 23 Dec 2018, accepted on 23 Jan 2019 and first published on 24 Jan 2019


Article type: Paper
DOI: 10.1039/C8OB03189D
Citation: Org. Biomol. Chem., 2019, Advance Article

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    Aryltrifluoromethylative cyclization of unactivated alkenes by the use of PhICF3Cl under catalyst-free conditions

    J. Guo, C. Xu, X. Liu and M. Wang, Org. Biomol. Chem., 2019, Advance Article , DOI: 10.1039/C8OB03189D

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