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Issue 12, 2019
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Catalytic enantioselective iodolactonization reactions

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The halolactonization reaction is a useful chemical transformation for the construction of lactones from γ- or δ-substituted alkenoic carboxylic acids or carboxylic esters. Traditionally, the stereoselectivity of these reactions has been controlled by the substrates or the reagents. The substrate-controlled method has been extensively studied and applied in the synthesis of many natural products. However, catalytic, enantioselective iodolactonizations of γ- or δ-substituted alkenoic carboxylic acids have only recently been developed. This review article highlights the advances that have emerged over the last decade.

Graphical abstract: Catalytic enantioselective iodolactonization reactions

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Publication details

The article was received on 20 Dec 2018, accepted on 19 Feb 2019 and first published on 19 Feb 2019

Article type: Review Article
DOI: 10.1039/C8OB03160F
Org. Biomol. Chem., 2019,17, 3079-3092

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    Catalytic enantioselective iodolactonization reactions

    R. Kristianslund, J. E. Tungen and T. V. Hansen, Org. Biomol. Chem., 2019, 17, 3079
    DOI: 10.1039/C8OB03160F

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