SCHEDULED MAINTENANCE
Total synthesis of (±)-galanthamine from GABA through regioselective aryne insertion†
Prathama S.
Mainkar 
ab
and
Srivari
Chandrasekhar
*ab
ab
and
Srivari
Chandrasekhar
*ab
Abstract
The total synthesis of (±)-galanthamine is achieved in ∼5% overall yield using a key regioselective aryne insertion reaction into a GABA (γ-amino butyric acid) derivative. The strategy presented involves only two sub-critical temperature reactions and less than five chromatographic purifications to achieve the synthesis of galanthamine.
- This article is part of the themed collection: Total synthesis in OBC
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