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Issue 8, 2019
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Total synthesis of (±)-galanthamine from GABA through regioselective aryne insertion

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Abstract

The total synthesis of (±)-galanthamine is achieved in ∼5% overall yield using a key regioselective aryne insertion reaction into a GABA (γ-amino butyric acid) derivative. The strategy presented involves only two sub-critical temperature reactions and less than five chromatographic purifications to achieve the synthesis of galanthamine.

Graphical abstract: Total synthesis of (±)-galanthamine from GABA through regioselective aryne insertion

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Publication details

The article was received on 17 Dec 2018, accepted on 28 Jan 2019 and first published on 28 Jan 2019


Article type: Paper
DOI: 10.1039/C8OB03123A
Org. Biomol. Chem., 2019,17, 2192-2198

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    Total synthesis of (±)-galanthamine from GABA through regioselective aryne insertion

    T. Venkatesh, P. S. Mainkar and S. Chandrasekhar, Org. Biomol. Chem., 2019, 17, 2192
    DOI: 10.1039/C8OB03123A

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