Issue 8, 2019
From the journal:

Organic & Biomolecular Chemistry

Abinukitrine A, a unique 17,18-cyclolanostane triterpenoid from Abies nukiangensis†

Yong-Li Li, ORCID logo *a   Li-Jun Xue,c   Jie Li,a   Li-Ming Chen,a   Jian-Jun Wu,a   Zhuo-Ni Xu,a   Ying Chen,a   Yu-Ping Tiana  and  Xian-Wen Yang ORCID logo *b  

* Corresponding authors

a Physical and Chemical Analysis laboratory, Division of Material Science & Quality Test, Shanghai Institute of Measurement and Testing Technology, 1500 Zhangheng Road, Shanghai 201203, China
E-mail: liyl@simt.com.cn

b Key Laboratory of Marine Biogenetic Resources, Third Institute of Oceanography, Ministry of Natural Resources, 184 Daxue Road, Xiamen 361005, China
E-mail: yangxianwen@tio.org.cn

c Department of Medical Oncology, Jinling Hospital, Nanjing University Clinical School of Medicine, 305 East Zhongshan Road, Nanjing, China

Abstract

Abinukitrine A (1), a novel triterpenoid, was isolated from Abies nukiangensis. Comprehensive spectroscopic analysis revealed that 1 is the first example of 17,18-cyclolanostane bearing a unique 6/6/6/5/3 ring system. Its absolute configuration was unequivocally assigned by Cu-Kα X-ray single-crystallography. Compound 1 showed a potent anti-hepatitis C virus (HCV) effect.

Graphical abstract: Abinukitrine A, a unique 17,18-cyclolanostane triterpenoid from Abies nukiangensis

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Article information

DOI
https://doi.org/10.1039/C8OB03117G
Article type
Communication
Submitted
16 Dec 2018
Accepted
29 Jan 2019
First published
30 Jan 2019

Org. Biomol. Chem., 2019,17, 2107-2109

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Abinukitrine A, a unique 17,18-cyclolanostane triterpenoid from Abies nukiangensis

Y. Li, L. Xue, J. Li, L. Chen, J. Wu, Z. Xu, Y. Chen, Y. Tian and X. Yang, Org. Biomol. Chem., 2019, 17, 2107 DOI: 10.1039/C8OB03117G

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