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Issue 8, 2019
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Metal-free synthesis of 2,2-disubstituted indolin-3-ones

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Abstract

A straightforward method for the synthesis of indolin-3-ones bearing a C2-quaternary functionality is reported. A series of 2,2-disubstituted indolin-3-ones were constructed in up to 94% yields in the absence of a metal catalyst. This cross-coupling reaction allows the facile synthesis of 2,2-disubstituted indolin-3-ones from readily available substrates in a short reaction time.

Graphical abstract: Metal-free synthesis of 2,2-disubstituted indolin-3-ones

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Publication details

The article was received on 12 Dec 2018, accepted on 28 Jan 2019 and first published on 29 Jan 2019


Article type: Paper
DOI: 10.1039/C8OB03057J
Citation: Org. Biomol. Chem., 2019,17, 2199-2203

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    Metal-free synthesis of 2,2-disubstituted indolin-3-ones

    X. Jiang, B. Zhu, K. Lin, G. Wang, W. Su and C. Yu, Org. Biomol. Chem., 2019, 17, 2199
    DOI: 10.1039/C8OB03057J

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