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Efficient two-step synthesis of structurally diverse indolo[2,3-b]quinoline derivatives

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Abstract

A general and efficient synthesis of diverse tetracyclic indolo[2,3-b]quinoline derivatives was achieved through palladium-catalyzed domino carboannulation/cross-coupling and DDQ-mediated double cross-dehydrogenative C–N bond formation. This approach provides a straightforward, atom-economical and concise route to easily access a diverse range of tetracyclic indolo[2,3-b]quinolines and their analogues in excellent yields with good tolerance of functional groups.

Graphical abstract: Efficient two-step synthesis of structurally diverse indolo[2,3-b]quinoline derivatives

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Publication details

The article was received on 05 Dec 2018, accepted on 30 Jan 2019 and first published on 31 Jan 2019


Article type: Communication
DOI: 10.1039/C8OB03033B
Citation: Org. Biomol. Chem., 2019, Advance Article

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    Efficient two-step synthesis of structurally diverse indolo[2,3-b]quinoline derivatives

    S. Kundal, B. Chakraborty, K. Paul and U. Jana, Org. Biomol. Chem., 2019, Advance Article , DOI: 10.1039/C8OB03033B

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