Jump to main content
Jump to site search


Synthesis of cyano-substituted carbazoles via successive C–C/C–H cleavage

Author affiliations

Abstract

A highly efficient protocol for the synthesis of polysubstituted cyano carbazoles has been developed. This process is realized through the tandem reactions of Cs2CO3 promoted C–C σ-bond activation of α-cyano ketones followed by Fe-catalyzed selective C–H and/or C–C bond activations. Two of the sp2 C–H bonds are functionalized, and two of the C–C σ-bonds are cleaved involving a 1,2-acyl migration during the reaction process.

Graphical abstract: Synthesis of cyano-substituted carbazoles via successive C–C/C–H cleavage

Back to tab navigation

Supplementary files

Publication details

The article was received on 05 Dec 2018, accepted on 03 Jan 2019 and first published on 04 Jan 2019


Article type: Paper
DOI: 10.1039/C8OB03031F
Citation: Org. Biomol. Chem., 2019, Advance Article
  •   Request permissions

    Synthesis of cyano-substituted carbazoles via successive C–C/C–H cleavage

    Y. Yang, J. Huang, H. Tan, L. Kong, M. Wang, Y. Yuan and Y. Li, Org. Biomol. Chem., 2019, Advance Article , DOI: 10.1039/C8OB03031F

Search articles by author

Spotlight

Advertisements