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tert-Butyl nitrite promoted transamidation of secondary amides under metal and catalyst free conditions

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Abstract

A mild and efficient method is demonstrated for the transamidation of secondary amides with various amines including primary, secondary, cyclic and acyclic amines in the presence of tert-butyl nitrite. The reaction proceeds through the N-nitrosamide intermediate and provides the transamidation products in good to excellent yields at room temperature. Moreover, the developed methodology does not require any catalyst or additives.

Graphical abstract: tert-Butyl nitrite promoted transamidation of secondary amides under metal and catalyst free conditions

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Publication details

The article was received on 03 Dec 2018, accepted on 02 Jan 2019 and first published on 02 Jan 2019


Article type: Paper
DOI: 10.1039/C8OB03010C
Citation: Org. Biomol. Chem., 2019, Advance Article
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    tert-Butyl nitrite promoted transamidation of secondary amides under metal and catalyst free conditions

    P. Sureshbabu, S. Azeez, P. Chaudhary and J. Kandasamy, Org. Biomol. Chem., 2019, Advance Article , DOI: 10.1039/C8OB03010C

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