Issue 16, 2019

A novel multicomponent quadruple/double quadruple domino reaction: highly efficient synthesis of polyheterocyclic architectures

Abstract

A novel multicomponent quadruple domino reaction (MCQDR) for the assembly of structurally complex molecular architectures via the formation of three rings and three contiguous stereogenic centers has been accomplished with high regio- and diastereoselectivity. Solvents, catalysts and work-up were not required to obtain the target molecules. In addition, this new protocol is also extended for the multicomponent double quadruple domino reaction (MCDQDR) to create novel polyheterocyclic architectures in an orthogonal manner.

Graphical abstract: A novel multicomponent quadruple/double quadruple domino reaction: highly efficient synthesis of polyheterocyclic architectures

Supplementary files

Article information

Article type
Paper
Submitted
28 Nov 2018
Accepted
12 Dec 2018
First published
12 Dec 2018

Org. Biomol. Chem., 2019,17, 3884-3893

A novel multicomponent quadruple/double quadruple domino reaction: highly efficient synthesis of polyheterocyclic architectures

M. Bakthadoss, S. Jayakumar, S. Raman, A. Devaraj and D. S. Sharada, Org. Biomol. Chem., 2019, 17, 3884 DOI: 10.1039/C8OB02970A

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements