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Efficient synthesis and characterisation of the amyloid beta peptide, Aβ1–42, using a double linker system

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Abstract

The amyloidogenic Aβ42 peptide was efficiently prepared using a double linker system, markedly improving solubility and chromatographic peak resolution, thus enabling full characterisation using standard techniques. The tag was readily cleaved with sodium hydroxide and removed by aqueous extraction, affording Aβ42 in high purity and yield for biophysical characterisation studies.

Graphical abstract: Efficient synthesis and characterisation of the amyloid beta peptide, Aβ1–42, using a double linker system

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Publication details

The article was received on 23 Nov 2018, accepted on 26 Nov 2018 and first published on 26 Nov 2018


Article type: Communication
DOI: 10.1039/C8OB02929F
Citation: Org. Biomol. Chem., 2019, Advance Article
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    Efficient synthesis and characterisation of the amyloid beta peptide, Aβ1–42, using a double linker system

    J. K. Kasim, I. Kavianinia, J. Ng, P. W. R. Harris, N. P. Birch and M. A. Brimble, Org. Biomol. Chem., 2019, Advance Article , DOI: 10.1039/C8OB02929F

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