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Base-promoted direct synthesis of functionalized N-arylindoles via the cascade reactions of allenic ketones with indoles

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Abstract

A convenient Cs2CO3-promoted cascade benzannulation reaction of allenic ketones with indoles was achieved for the synthesis of functionalized N-arylindole derivatives under transition-metal-free conditions. A series of readily available starting materials can undergo the process successfully. It represents a practical method for the construction of N-arylindole scaffolds with high atom economy.

Graphical abstract: Base-promoted direct synthesis of functionalized N-arylindoles via the cascade reactions of allenic ketones with indoles

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Publication details

The article was received on 23 Nov 2018, accepted on 27 Dec 2018 and first published on 28 Dec 2018


Article type: Communication
DOI: 10.1039/C8OB02921K
Citation: Org. Biomol. Chem., 2019, Advance Article
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    Base-promoted direct synthesis of functionalized N-arylindoles via the cascade reactions of allenic ketones with indoles

    S. Li, X. Wu and S. Chen, Org. Biomol. Chem., 2019, Advance Article , DOI: 10.1039/C8OB02921K

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