Silver(i)-catalyzed addition of pyridine-N-oxides to alkynes: a practical approach for N-alkenoxypyridinium salts†
Abstract
A smooth catalytic approach to N-alkenoxypyridinium salts by using pyridine-N-oxides as the nucleophilic partner with alkynes under acidic conditions has been developed. This method uses different Ag(I) salts, with 5% AgOAc being the most efficient, to provide an efficient, practical and alternative way to obtain valuable N-alkenoxypyridinium salts with good to excellent yields (up to 93%).
- This article is part of the themed collection: Synthetic methodology in OBC