Issue 4, 2019

Design and synthesis of N1,N8-diacetylspermidine analogues having a linker with desired functional groups

Abstract

The synthesis of new N1,N8-diacetylspermidine (DiAcSpd) analogues having a linker with desired functional groups in the methylene skeleton, which have been designed by theoretical calculations, is described. We have also achieved the preparation of DiAcSpd supported on solid-phase resins, which have the potential to be used for the evolution of ligands by exponential enrichment (SELEX).

Graphical abstract: Design and synthesis of N1,N8-diacetylspermidine analogues having a linker with desired functional groups

Supplementary files

Article information

Article type
Paper
Submitted
20 Nov 2018
Accepted
20 Dec 2018
First published
20 Dec 2018

Org. Biomol. Chem., 2019,17, 867-875

Author version available

Design and synthesis of N1,N8-diacetylspermidine analogues having a linker with desired functional groups

R. Ohta, A. Oguro, K. Nishimura, K. Murai, H. Fujioka and M. Arisawa, Org. Biomol. Chem., 2019, 17, 867 DOI: 10.1039/C8OB02900H

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