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Design and synthesis of N1,N8-diacetylspermidine analogues having a linker with desired functional groups

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Abstract

The synthesis of new N1,N8-diacetylspermidine (DiAcSpd) analogues having a linker with desired functional groups in the methylene skeleton, which have been designed by theoretical calculations, is described. We have also achieved the preparation of DiAcSpd supported on solid-phase resins, which have the potential to be used for the evolution of ligands by exponential enrichment (SELEX).

Graphical abstract: Design and synthesis of N1,N8-diacetylspermidine analogues having a linker with desired functional groups

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Publication details

The article was received on 20 Nov 2018, accepted on 20 Dec 2018 and first published on 20 Dec 2018


Article type: Paper
DOI: 10.1039/C8OB02900H
Citation: Org. Biomol. Chem., 2019, Advance Article
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    Design and synthesis of N1,N8-diacetylspermidine analogues having a linker with desired functional groups

    R. Ohta, A. Oguro, K. Nishimura, K. Murai, H. Fujioka and M. Arisawa, Org. Biomol. Chem., 2019, Advance Article , DOI: 10.1039/C8OB02900H

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