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Palladium-catalysed ring-opening [3 + 2]-annulation of spirovinylcyclopropyl oxindole to diastereoselectively access spirooxindoles

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Abstract

A novel palladium-catalysed ring-opening [3 + 2]-annulation of spirovinylcyclopropyl oxindole with α,β-unsaturated nitroalkenes is reported. A series of spirooxindole derivatives were synthesized in high yields and good to excellent diastereoselectivities. This developed protocol offers a new and efficient pathway for the assembly of spirooxindoles.

Graphical abstract: Palladium-catalysed ring-opening [3 + 2]-annulation of spirovinylcyclopropyl oxindole to diastereoselectively access spirooxindoles

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Publication details

The article was received on 16 Nov 2018, accepted on 28 Nov 2018 and first published on 29 Nov 2018


Article type: Paper
DOI: 10.1039/C8OB02859A
Citation: Org. Biomol. Chem., 2019, Advance Article
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    Palladium-catalysed ring-opening [3 + 2]-annulation of spirovinylcyclopropyl oxindole to diastereoselectively access spirooxindoles

    J. Xiao, X. Cheng, Y. Li, Y. He, J. Li, Z. Liu, P. Xia, W. Su and H. Yang, Org. Biomol. Chem., 2019, Advance Article , DOI: 10.1039/C8OB02859A

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