Issue 1, 2019

Palladium-catalysed ring-opening [3 + 2]-annulation of spirovinylcyclopropyl oxindole to diastereoselectively access spirooxindoles

Abstract

A novel palladium-catalysed ring-opening [3 + 2]-annulation of spirovinylcyclopropyl oxindole with α,β-unsaturated nitroalkenes is reported. A series of spirooxindole derivatives were synthesized in high yields and good to excellent diastereoselectivities. This developed protocol offers a new and efficient pathway for the assembly of spirooxindoles.

Graphical abstract: Palladium-catalysed ring-opening [3 + 2]-annulation of spirovinylcyclopropyl oxindole to diastereoselectively access spirooxindoles

Supplementary files

Article information

Article type
Paper
Submitted
16 Nov 2018
Accepted
28 Nov 2018
First published
29 Nov 2018

Org. Biomol. Chem., 2019,17, 103-107

Palladium-catalysed ring-opening [3 + 2]-annulation of spirovinylcyclopropyl oxindole to diastereoselectively access spirooxindoles

J. Xiao, X. Cheng, Y. Li, Y. He, J. Li, Z. Liu, P. Xia, W. Su and H. Yang, Org. Biomol. Chem., 2019, 17, 103 DOI: 10.1039/C8OB02859A

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