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Recent advances in transition metal-catalyzed C(sp2)–H nitration

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Abstract

Nitroaromatic compounds play an important role in organic synthesis, medicinal chemistry and chemical industry. Among the recently reported synthetic methods to access nitroarenes, transition metal-catalyzed C(sp2)–H activation/nitration has become one of the most attractive protocols, showing high regioselectivity, excellent functional group tolerance and step-economy. In this review, we discuss advances in direct C(sp2)–H nitration for the synthesis of nitroaromatic compounds and mechanistic insights over the past decade. We hope this will provide valuable information for researchers interested in the rapidly developing field of metal-catalyzed C(sp2)–H nitration.

Graphical abstract: Recent advances in transition metal-catalyzed C(sp2)–H nitration

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Publication details

The article was received on 06 Nov 2018, accepted on 02 Jan 2019 and first published on 03 Jan 2019


Article type: Review Article
DOI: 10.1039/C8OB02750A
Citation: Org. Biomol. Chem., 2019, Advance Article
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    Recent advances in transition metal-catalyzed C(sp2)–H nitration

    L. Song, Z. Fan and A. Zhang, Org. Biomol. Chem., 2019, Advance Article , DOI: 10.1039/C8OB02750A

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