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Issue 6, 2019
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Recent advances in transition metal-catalyzed C(sp2)–H nitration

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Abstract

Nitroaromatic compounds play an important role in organic synthesis, medicinal chemistry and chemical industry. Among the recently reported synthetic methods to access nitroarenes, transition metal-catalyzed C(sp2)–H activation/nitration has become one of the most attractive protocols, showing high regioselectivity, excellent functional group tolerance and step-economy. In this review, we discuss advances in direct C(sp2)–H nitration for the synthesis of nitroaromatic compounds and mechanistic insights over the past decade. We hope this will provide valuable information for researchers interested in the rapidly developing field of metal-catalyzed C(sp2)–H nitration.

Graphical abstract: Recent advances in transition metal-catalyzed C(sp2)–H nitration

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Article information


Submitted
06 Nov 2018
Accepted
02 Jan 2019
First published
03 Jan 2019

Org. Biomol. Chem., 2019,17, 1351-1361
Article type
Review Article

Recent advances in transition metal-catalyzed C(sp2)–H nitration

L. Song, Z. Fan and A. Zhang, Org. Biomol. Chem., 2019, 17, 1351
DOI: 10.1039/C8OB02750A

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