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Issue 3, 2019
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Tuning the properties of a cyclic RGD-containing tetrapeptide through backbone fluorination

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Abstract

Stereoselective fluorination is investigated as a method for modulating the properties of a cyclic RGD-containing tetrapeptide. Three key outcomes of fluorination are assessed: (i) the effect on peptide cyclisation efficiency; (ii) the ability to fine-tune the molecular conformation; and (iii) the effect on the cyclic peptides’ biological activity. Fluorination is found to exert pronounced effects against all three criteria.

Graphical abstract: Tuning the properties of a cyclic RGD-containing tetrapeptide through backbone fluorination

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Publication details

The article was received on 30 Oct 2018, accepted on 14 Dec 2018 and first published on 14 Dec 2018


Article type: Paper
DOI: 10.1039/C8OB02679C
Citation: Org. Biomol. Chem., 2019,17, 664-674

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    Tuning the properties of a cyclic RGD-containing tetrapeptide through backbone fluorination

    C. Au, C. Gonzalez, Y. C. Leung, F. Mansour, J. Trinh, Z. Wang, X. Hu, R. Griffith, E. Pasquier and L. Hunter, Org. Biomol. Chem., 2019, 17, 664
    DOI: 10.1039/C8OB02679C

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