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Issue 3, 2019
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Cascade reaction based synthetic strategies targeting biologically intriguing indole polycycles

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Abstract

Indole polycycles are common structural frameworks of biologically intriguing small molecules of natural and synthetic origin and therefore remain interesting and challenging synthetic targets. Cascade reactions wherein a number of reactions occur in a sequential manner in the same reaction apparatus are highly efficient chemical processes which quickly build up molecular complexity. Synthetic approaches based on cascade reactions are highly useful as they tend to avoid multiple reaction work-up steps as well as purifications of all intermediary products. Therefore, in the last decade, a number of cascade reaction based approaches to build various molecular scaffolds of biological interest have been reported. However, a relatively smaller number of cascade reaction based synthetic strategies have targeted the indole polycycles. In this article, we have summarized some interesting cascade reaction based synthesis designs leading to complex indole polycycles including some biologically intriguing and natural product inspired indole frameworks.

Graphical abstract: Cascade reaction based synthetic strategies targeting biologically intriguing indole polycycles

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Article information


Submitted
22 Oct 2018
Accepted
27 Nov 2018
First published
27 Nov 2018

This article is Open Access

Org. Biomol. Chem., 2019,17, 413-431
Article type
Review Article

Cascade reaction based synthetic strategies targeting biologically intriguing indole polycycles

M. G. Ciulla, S. Zimmermann and K. Kumar, Org. Biomol. Chem., 2019, 17, 413
DOI: 10.1039/C8OB02620C

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