Jump to main content
Jump to site search


A mitochondria-targeted near-infrared fluorescent probe with a large Stokes shift for real-time detection of hypochlorous acid

Author affiliations

Abstract

Hypochlorous acid (HOCl) has been known to be intertwined with various pathophysiological processes. In this paper, a novel mitochondria-targeted near-infrared (NIR) fluorescent probe L based on a chromenylium-phenothiazine conjugate has been designed and synthesized for the detection of hypochlorous acid. Due to the HOCl-promoted intramolecular charge transfer processes, the probe L shows near-infrared fluorescence emission at 672 nm, large Stokes shifts of 97 nm, fast response, and high selectivity and sensitivity. Furthermore, the probe L is biocompatible, cell-membrane permeable and mitochondria-targetable, and can be used for endogenous HOCl imaging in living cells.

Graphical abstract: A mitochondria-targeted near-infrared fluorescent probe with a large Stokes shift for real-time detection of hypochlorous acid

Back to tab navigation

Supplementary files

Publication details

The article was received on 17 Oct 2018, accepted on 29 Nov 2018 and first published on 29 Nov 2018


Article type: Paper
DOI: 10.1039/C8OB02583E
Citation: Org. Biomol. Chem., 2019, Advance Article
  •   Request permissions

    A mitochondria-targeted near-infrared fluorescent probe with a large Stokes shift for real-time detection of hypochlorous acid

    X. Jiao, K. Huang, S. He, C. Liu, L. Zhao and X. Zeng, Org. Biomol. Chem., 2019, Advance Article , DOI: 10.1039/C8OB02583E

Search articles by author

Spotlight

Advertisements