Jump to main content
Jump to site search

Issue 2, 2019
Previous Article Next Article

A diversity of alkylation/acylation products of uracil and its derivatives: synthesis and a structural study

Author affiliations

Abstract

tert-Butyl dicarbonate (Boc2O) and ethyl iodide (EtI) reactions with uracil (U), thymine (T) and 6-methyluracil (6-MU) were performed following routine procedures in pyridine/DMF solvents and with DMAP as the catalyst. Among 20 synthesized compounds, a derivative of 6-methyluracil substituted by the Boc-pyridine moiety at the C5 position appeared unexpectedly. The NMR spectra confirmed the molecular structure of all uracil derivatives. Parallel quantum mechanical DFT calculations supported the experimental findings.

Graphical abstract: A diversity of alkylation/acylation products of uracil and its derivatives: synthesis and a structural study

Back to tab navigation

Supplementary files

Publication details

The article was received on 15 Oct 2018, accepted on 10 Dec 2018 and first published on 10 Dec 2018


Article type: Paper
DOI: 10.1039/C8OB02552E
Citation: Org. Biomol. Chem., 2019,17, 354-362

  •   Request permissions

    A diversity of alkylation/acylation products of uracil and its derivatives: synthesis and a structural study

    O. Michalak, P. Cmoch, P. Krzeczyński, M. Cybulski and A. Leś, Org. Biomol. Chem., 2019, 17, 354
    DOI: 10.1039/C8OB02552E

Search articles by author

Spotlight

Advertisements