Jump to main content
Jump to site search


Base mediated green synthesis of enantiopure 2-C-spiro-glycosyl-3-nitrochromenes

Author affiliations

Abstract

A novel green synthetic methodology has been developed to obtain enantiopure (2S)-2-C-spiro-glycosyl-3-nitrochromenes following the oxa-Michael–aldol condensation reaction of sugar derived 3-C-vinyl nitro olefins with substituted salicylaldehydes using Et3N as a base under neat conditions at rt–40 °C. The stereochemistry of the product is confirmed by a single crystal X-ray study. Several advantages are associated with this protocol such as cost effectiveness, easy accessibility, short reaction time, high yields, wide substrate scope and high enantiopurity.

Graphical abstract: Base mediated green synthesis of enantiopure 2-C-spiro-glycosyl-3-nitrochromenes

Back to tab navigation

Supplementary files

Publication details

The article was received on 14 Sep 2018, accepted on 19 Nov 2018 and first published on 19 Nov 2018


Article type: Paper
DOI: 10.1039/C8OB02278J
Citation: Org. Biomol. Chem., 2019, Advance Article
  •   Request permissions

    Base mediated green synthesis of enantiopure 2-C-spiro-glycosyl-3-nitrochromenes

    S. Nayak, P. Panda, B. P. Raiguru, S. Mohapatra and C. S. Purohit, Org. Biomol. Chem., 2019, Advance Article , DOI: 10.1039/C8OB02278J

Search articles by author

Spotlight

Advertisements