Issue 2, 2019

Investigation of tetrazine reactivity towards C-nucleophiles: pyrazolone-based modification of biomolecules

Abstract

Chemoselective, biocompatible ligation reactions are the key components for efficient and modular access to biomolecular scaffolds. Tetrazine ligation leads to the formation of a mixture of isomers, which makes reaction monitoring, purification and characterization of conjugates difficult. We report herein a modified tetrazine ligation strategy based on the use of a pyrazolone coupling partner, which provides a single molecule conjugate.

Graphical abstract: Investigation of tetrazine reactivity towards C-nucleophiles: pyrazolone-based modification of biomolecules

Supplementary files

Article information

Article type
Paper
Submitted
28 Aug 2018
Accepted
06 Dec 2018
First published
06 Dec 2018

Org. Biomol. Chem., 2019,17, 388-396

Investigation of tetrazine reactivity towards C-nucleophiles: pyrazolone-based modification of biomolecules

K. Renault, C. Guillou, P. Renard and C. Sabot, Org. Biomol. Chem., 2019, 17, 388 DOI: 10.1039/C8OB02108B

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements