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The Surface-enhanced Raman Scattering detection of N-Nitrosodimethylamine and N-Nitrosodiethylamine via gold nanorod arrays with a chemical linkage of zwitterionic copolymer

Abstract

Due to the emerging issue of the contaminations of sartan medicines and drink water with N-Nitrosodimethylamine (NDMA) and/or N-Nitrosodiethylamine (NDEA), the detection of NDMA/NDEA becomes an important theme. In this study, we utilized the focused ion beam to fabricate gold nanorods (AuNRs) Surface Enhanced Raman Scattering (SERS) substrates and modified with 1,2-ethanedithiol to quench the high luminescence excitation background signals derived from the high density of localized surface plasmon resonance. To improve surface hydrophilicity, zwitterionic copolymer PGMA-r-PSBMA was grafted onto the nanosurface of AuNRs, being certified with contact angle analysis and AFM. Raman spectra of the copolymer were observed to confirm the successful graft in AuNRs, also being corroborated by TEM and SEM. NDMA and NDEA, polar small molecules, in aqueous solutions were easily taken in AuNRs with the strong zwitterionic hydrophilicity. Furthermore, the self-association of anions and cations of polymeric chain grafted in the hot spot zone assists in capturing NDMA/NDEA polar molecules. The plasmon resonance energy in the hot spot region could be transferred through the chemical linkage of 1,2-ethanedithiol and zwitterionic copolymer to NDMA/NDEA between anions and cations. Accordingly, for the first time we detect the characteristic peaks of NDMA/NDEA through SERS with both detecting limits of 10-8M. Introduction

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Publication details

The article was accepted on 02 Dec 2019 and first published on 03 Dec 2019


Article type: Paper
DOI: 10.1039/C9NR09404K
Nanoscale, 2019, Accepted Manuscript

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    The Surface-enhanced Raman Scattering detection of N-Nitrosodimethylamine and N-Nitrosodiethylamine via gold nanorod arrays with a chemical linkage of zwitterionic copolymer

    T. Wen, C. Lin, P. Wang, T. Wang and L. Yang, Nanoscale, 2019, Accepted Manuscript , DOI: 10.1039/C9NR09404K

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