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Exploiting the protein corona: coating of black phosphorus nanosheets enables macrophage polarization via calcium influx

Abstract

Black phosphorus nanosheets (BPNSs) have substantially promoted biomedical nanotechnology due to their unique photothermal and chemotherapeutic properties. However, there is still a limited molecular understanding of the effects of bio-nano interfaces on BPNSs and the subsequent impacts on physiological systems. Here, it is showed that black phosphorus-corona complexes (BPCCs) could function as immune modulators to promote the polarization of macrophages. Mechanistically, BPCCs could interact with calmodulin to activate stromal interaction molecule 2 and facilitate Ca2+ influx in macrophages, which induced the activation of p38 and NF-κB and polarized M0 macrophages to the M1 phenotype. As a result, BPCC-activated macrophages show greater migration towards cancer cells, 1.3-1.9 times higher cellular cytotoxicity and effective phagocytosis of cancer cells. These findings offer insights into the development of potential and unique applications of corona on BPNSs in nanomedicine.

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Supplementary files

Publication details

The article was received on 06 Oct 2019, accepted on 02 Dec 2019 and first published on 02 Dec 2019


Article type: Paper
DOI: 10.1039/C9NR08570J
Nanoscale, 2019, Accepted Manuscript

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    Exploiting the protein corona: coating of black phosphorus nanosheets enables macrophage polarization via calcium influx

    J. Mo, Y. Xu, X. Wang, W. wei and J. Zhao, Nanoscale, 2019, Accepted Manuscript , DOI: 10.1039/C9NR08570J

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