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Metallo-responsive self-assembly of lipophilic guanines in hydrocarbon solvents: a systematic SAXS structural characterization

Abstract

Lipophilic guanines (LipoGs) in aprotic solvents undergo different self-assembly processes based on different H-bonded motifs. Cylindrical nanotubes made by π-π stacked guanine tetramers (G-quadruplexes) and flat, tape-like aggregates (G-ribbons) have been observed depending on the presence of alkali metal ions. To derive information on the structural properties and stability of these LipoG aggregates, Small-Angle X-ray Scattering (SAXS) experiments have been performed in dodecane, both in the presence and in the absence of potassium ions. As a result, the occurrence of the two different metallo-responsive architectures (nanoribbons or columnar nanotubes) was confirmed and we reported here for the first time a systematic study on the dependence of the aggregate properties on composition, temperature and molecular units structure. Even if dodecane was selected to favour LipoG solubility, a strong tendency to self-organization into ordered lyotropic phases was indeed detected.

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Publication details

The article was received on 05 Oct 2019, accepted on 02 Dec 2019 and first published on 04 Dec 2019


Article type: Paper
DOI: 10.1039/C9NR08556D
Nanoscale, 2019, Accepted Manuscript

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    Metallo-responsive self-assembly of lipophilic guanines in hydrocarbon solvents: a systematic SAXS structural characterization

    A. Gonnelli, S. Pieraccini, E. J. Baldassarri, S. S. Funari, S. Masiero, M. G. Ortore and P. Mariani, Nanoscale, 2019, Accepted Manuscript , DOI: 10.1039/C9NR08556D

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