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Aqueous Stable Pd Nanoparticles/Covalent Organic Framework Nanocomposite: An Efficient Nanoenzyme for Colorimetric Detection and Multicolor Imaging of Cancer Cells

Abstract

Accurate, sensitive detection of cancer cells from clinical fluids is helpful for screening and early diagnosis of the tumor. Here we develop a facile approach for in situ growth of palladium nanoparticles in aqueous stable carboxymethyl cellulose modified covalent organic framework hydrogel (named as Pd NPs/CMC-COF-LZU1). The resulting nanocomposite nanoenzyme has been proven to have a superior catalytic performance for the transformation of N-butyl-4-NHAlloc-1,8-naphthalimide (NNPH) into N-butyl-4-amido-1,8-naphthalimide (NPH), resulting in significant changes in both color and fluorescence. Based on these features, the designed nanocomposite was used as a signal transducer to develop a colorimetric assay and multicolor imaging for accurate and sensitive cancer cell detection. The transformation of NNPH into NPH enabled the detection system to perform multicolor imaging of HeLa cells. By using folic acid (FA) as a recognition element, a total of 100 cancer cells (HeLa) can be distinguished a total of 100 cancer cells (HeLa) can be distinguished in 1 mL culture medium with 10% FBS. We envision that these COF-based composite materials (Pd NPs/CMC-COF-LZU1) have tremendous potential applications in biotechnology and biological science.

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Supplementary files

Publication details

The article was received on 03 Oct 2019, accepted on 16 Nov 2019 and first published on 18 Nov 2019


Article type: Paper
DOI: 10.1039/C9NR08486J
Nanoscale, 2019, Accepted Manuscript

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    Aqueous Stable Pd Nanoparticles/Covalent Organic Framework Nanocomposite: An Efficient Nanoenzyme for Colorimetric Detection and Multicolor Imaging of Cancer Cells

    P. Sun, J. Hai, S. Sun, S. Lu, S. Liu, H. Liu, F. Chen and B. Wang, Nanoscale, 2019, Accepted Manuscript , DOI: 10.1039/C9NR08486J

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