Jump to main content
Jump to site search

Issue 47, 2019
Previous Article Next Article

Biodegradable hollow manganese/cobalt oxide nanoparticles for tumor theranostics

Author affiliations

Abstract

This article describes the fabrication of hollow manganese/cobalt oxide nanoparticles (MCO NPs) with a tunable size through a redox reaction and the Kirkendall effect for cancer imaging and drug delivery. MCO-70 NPs (with an average size of 70 nm) can act as glutathione (GSH)-responsive contrast agents for dual T1/T2-weighted magnetic resonance imaging (MRI). The degradation of MCO NPs by GSH led to the enhancement of their T1 and T2 signals by 2.24- and 3.43-fold compared with those of MCO NPs before degradation, respectively. Antitumor agents such as doxorubicin (Dox) could be encapsulated inside the cavity of the hollow MCO NPs (MCO-70-Dox) and be released in the presence of GSH. The MCO-70-Dox NPs showed good tumor growth inhibition effects in vitro and in vivo, and can be promising drug delivery vehicles and MRI contrast agents for tumor diagnosis and reporting drug release.

Graphical abstract: Biodegradable hollow manganese/cobalt oxide nanoparticles for tumor theranostics

Back to tab navigation

Supplementary files

Publication details

The article was received on 07 Sep 2019, accepted on 30 Oct 2019 and first published on 27 Nov 2019


Article type: Paper
DOI: 10.1039/C9NR07725A
Nanoscale, 2019,11, 23021-23026

  •   Request permissions

    Biodegradable hollow manganese/cobalt oxide nanoparticles for tumor theranostics

    Q. Ren, K. Yang, R. Zou, Z. Wan, Z. Shen, G. Wu, Z. Zhou, Q. Ni, W. Fan, J. Hu and Y. Liu, Nanoscale, 2019, 11, 23021
    DOI: 10.1039/C9NR07725A

Search articles by author

Spotlight

Advertisements