Issue 47, 2019

Biodegradable hollow manganese/cobalt oxide nanoparticles for tumor theranostics

Abstract

This article describes the fabrication of hollow manganese/cobalt oxide nanoparticles (MCO NPs) with a tunable size through a redox reaction and the Kirkendall effect for cancer imaging and drug delivery. MCO-70 NPs (with an average size of 70 nm) can act as glutathione (GSH)-responsive contrast agents for dual T1/T2-weighted magnetic resonance imaging (MRI). The degradation of MCO NPs by GSH led to the enhancement of their T1 and T2 signals by 2.24- and 3.43-fold compared with those of MCO NPs before degradation, respectively. Antitumor agents such as doxorubicin (Dox) could be encapsulated inside the cavity of the hollow MCO NPs (MCO-70-Dox) and be released in the presence of GSH. The MCO-70-Dox NPs showed good tumor growth inhibition effects in vitro and in vivo, and can be promising drug delivery vehicles and MRI contrast agents for tumor diagnosis and reporting drug release.

Graphical abstract: Biodegradable hollow manganese/cobalt oxide nanoparticles for tumor theranostics

Supplementary files

Article information

Article type
Paper
Submitted
07 Sep 2019
Accepted
30 Oct 2019
First published
27 Nov 2019

Nanoscale, 2019,11, 23021-23026

Biodegradable hollow manganese/cobalt oxide nanoparticles for tumor theranostics

Q. Ren, K. Yang, R. Zou, Z. Wan, Z. Shen, G. Wu, Z. Zhou, Q. Ni, W. Fan, J. Hu and Y. Liu, Nanoscale, 2019, 11, 23021 DOI: 10.1039/C9NR07725A

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements