Jump to main content
Jump to site search

Issue 48, 2019
Previous Article Next Article

Graphene oxide/alginate composites as novel bioinks for three-dimensional mesenchymal stem cell printing and bone regeneration applications

Author affiliations

Abstract

Three-dimensional (3D) cell printing is a versatile technique enabling the creation of 3D constructs containing hydrogel and cells in the desired shape or pattern. Bioinks exhibiting appropriate mechanical properties and biological activities to support cell growth and/or differentiation toward a specific lineage play critical roles in 3D cell printing and tissue engineering applications. Herein, we explored alginate/graphene oxide (GO) composites as bioinks for their potential to improve printability, structural stability, and osteogenic activities for osteogenic tissue engineering applications. The addition of GO (0.05–1.0 mg mL−1) to 3% alginate significantly enhanced the printing performances of the alginate bioink. In addition, mesenchymal stem cells (MSCs) printed with alginate/GO showed good proliferation and higher survival in an oxidative stress environment. The 3D scaffolds printed with MSCs and alginate/GO demonstrated significantly enhanced osteogenic differentiation compared with those printed with MSCs and alginate. Overall, a bioink of 3% alginate and 0.5 mg mL−1 GO showed the most balanced characteristics in terms of printability, structural stability, and osteogenic induction of the printed MSCs. Alginate/GO composite bioinks will be useful for bioprinting research for various tissue engineering applications.

Graphical abstract: Graphene oxide/alginate composites as novel bioinks for three-dimensional mesenchymal stem cell printing and bone regeneration applications

Back to tab navigation

Supplementary files

Publication details

The article was received on 04 Sep 2019, accepted on 20 Nov 2019 and first published on 23 Nov 2019


Article type: Paper
DOI: 10.1039/C9NR07643C
Nanoscale, 2019,11, 23275-23285

  •   Request permissions

    Graphene oxide/alginate composites as novel bioinks for three-dimensional mesenchymal stem cell printing and bone regeneration applications

    G. Choe, S. Oh, J. M. Seok, S. A. Park and J. Y. Lee, Nanoscale, 2019, 11, 23275
    DOI: 10.1039/C9NR07643C

Search articles by author

Spotlight

Advertisements